Derivative of phenylalkylacetic acid.



. No Drawing.

rated from the phosphoric acid. and the tered oil and crystallized from benzene.

"ists, citizens of the German Empire, resid-" possess antipyretic properties;

, by weight: 492 parts of phenyl-ethyl-acetici UNTED STATES WALTER KROPP AND LUDWIG 'IAUB, OF. ELBERFELD, GERMANY, ASSIGNORS TO BENFABRIKEN VORM. FRIEDR. RATION OF GERMANY;

DERIVATIVE OF --PHENYLAYLKYLACEQTIC acm To all whom it my concern! v Be it known that we, WALTER Kuorr and Lunwm TAUB., doctors of philosophy,;cheming at Elberfeld,.Gcrmany, have invented new and useful Improvements in New Derivatives of Phenylalkylac'etic Acids, of j which the followin is a specification.

Our invention re ates to the'manufacture and production of new valuable pharmaceutical products which are chemically the amid compounds of acids of the formula: I p

0H5 I V whichaccording to our researches are valuable sedatives and hypnotics which also The new rodu'cts are crystalline compounds soluble'in hot alcohol and hot ben- ,zene. When reacted .upon by hot alkalis they are split up into the phenyl-alkylaceticacid and ammonia or urea. p

. In carrying out our process practically we can proceed as follows, the'parts being acid-are heated to 100C. with 140 parts of 01 the product of. the reaction is'sepachlorid is distilled in 'vacuo. The chlorid of henyl-ethyl-acetic acid is then treated wit an excess of ammonia, the amid is fil- It is a white crystallinepowder melting at 86 phenyl alkyl acetic in hot alcohol and hot (3., soluble in-hot alcohol and hot benzene;

liberatin I the acid when reacted upon by caustic a kali and exhibiting valuable therapeutic especially sedative properties; an

average dose being from a; to 1 gram. The reaction proceeds in accordance with the peutic especially sedative properties, sub-- stantially as described.

2. The herein described new amid of phenyl-ethyl-acetic acid being a white crystalline compound meltin at 86 C., soluble enzene; liberating the acid when reacted upon by caustic alkali; exhibiting valuable therapeutic especially sedative properties, substantially as described.

In testimony whereof'we have hereunto Set our hands in the presence of two subscribing witnesses. I

WALTER KROPP. [n a] LUDWIG TAUB. [L- 5.] Witnesses: 4

- CHAS. J. WRIGHT,

ALFRED HENKEL.

BAYER 8a 00., OF ELBER FELD} GERMANY, A CORPO- I I. Specification of Letters Iatent. Patented J 11119 27 1911, Application filed March-a0, 1911. serial No. 615,649. 

